Cuvinte cheie
hypoxia
hypotension
mortality
prognosis
risk factors
secondary brain injury
Cum cităm
Rezumat
Introduction. Traumatic brain injury (TBI) remains a major global health burden, associated with high mortality and long-term disability. Secondary brain injury related to hypoxia and hypotension worsens outcomes, particularly in the prehospital stage.
Materials and methods. This retrospective observational study included 486 adult patients with acute TBI managed between 2020 and 2024 in the prehospital setting and in the Emergency Department of the Institute of Emergency Medicine, Chisinau, Republic of Moldova. Injury severity was assessed using the Glasgow Coma Scale. Associations between physiological parameters and clinical outcomes were analyzed using Pearson’s correlation coefficient.
Results. Advanced age, low systolic blood pressure, and prehospital hypoxia were significantly associated with greater TBI severity and increased mortality (p < 0.0001). Hypoxia showed a moderate positive correlation with both severity and mortality. Hyperglycemia was not associated with injury severity but correlated significantly with mortality.
Conclusions. Early recognition and correction of hypoxia and hypotension during prehospital care are essential to limit secondary brain injury and improve outcomes in patients with TBI.
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Copyright (c) 2026 Natalia MOCANU, Larisa REZNEAC, Natalia CATANOI, Tatiana MALACINSCHI-CODREANU, Elina SHOR